A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer
✍ Scribed by Wen-Chau Chen; Shao-Chieh Lin; Jenq-Chang Lee; 陳文超; 林劭潔; 李政昌
- Book ID
- 119316827
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 376 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0257-5655
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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
Communicated by Sauiu L.C. Woo We examined 18 unrelated individuals who have colorectal cancer or cancers associated with the HNPCC syndrome and have a family history of cancer for mutations in exon 13 of the hMSH2 gene. Two of the 18 individuals had the same previously unreported single-base delet