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Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

✍ Scribed by Chan, Tsun Leung; Yuen, Siu Tsan; Kong, Chi Kwan; Chan, Yee Wai; Chan, Annie SY; Ng, Wai Fu; Tsui, Wai Yin; Lo, Michelle WS; Tam, Wing Yip; Li, Vivian SW


Book ID
109919420
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
658 KB
Volume
38
Category
Article
ISSN
1061-4036

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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred