✦ LIBER ✦

Deletions Account for 17% of Pathogenic Germline Alterations in MLH1 and MSH2 in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Families

✍ Scribed by Grabowski, Monika; Mueller-Koch, Yvonne; Grasbon-Frodl, Eva; Koehler, Udo; Keller, Gisela; Vogelsang, Holger; Dietmaier, Wolfgang; Kopp, Reinhard; Siebers, Ulrike; Schmitt, Wolfgang; Neitzel, Birgit; Gruber, Maria; Doerner, Christa; Kerker, Brigitte; Ruemmele, Petra; Henke, Gabriele; Holinski-Feder, Elke

Book ID: 126986221
Publisher: Mary Ann Liebert
Year: 2005
Tongue: English
Weight: 173 KB
Volume: 9
Category: Article
ISSN: 1090-6576
DOI: 10.1089/gte.2005.9.138

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Seven novel MLH1 and MSH2 germline mutat

Seven novel MLH1 and MSH2 germline mutations in hereditary nonpolyposis colorectal cancer

✍ Stefan Krüger; Jens Plaschke; Steffen Pistorius; Birgit Jeske; Stephan Haas; Hei 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 32 KB 👁 1 views

Prevalence of germline mutations of MLH1

Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain

✍ Trinidad Caldes; Javier Godino; Miguel de la Hoya; Iciar Garcia Carbonero; Pedro 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 520 KB

## Abstract HNPCC is an autosomal dominantly inherited cancer‐susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract

Hereditary nonpolyposis colorectal cance

Hereditary nonpolyposis colorectal cancer: pitfalls in deletion screening in MSH2 and MLH1 genes

✍ Wehner, Maria; Mangold, Elisabeth; Sengteller, Marlies; Friedrichs, Nicolaus; Ar 📂 Article 📅 2005 🏛 Nature Publishing Group 🌐 English ⚖ 134 KB

Six novel heterozygous MLH1, MSH2, and M

Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer

✍ Jean-Marc Rey; Mehrdad Noruzinia; Jean-Paul Brouillet; Pierre Sarda; Thierry Mau 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 148 KB

Characterization of MSH2 and MLH1 mutati

Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer

✍ Alessandra Viel; Maurizio Genuardi; Eugenia Capozzi; Francesca Leonardi; Alfonso 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB 👁 2 views

Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred

Hereditary nonpolyposis colorectal cance

Hereditary nonpolyposis colorectal cancer: Frequent occurrence of large genomic deletions in MSH2 and MLH1 genes

✍ Yaping Wang; Waltraut Friedl; Christof Lamberti; Matthias Jungck; Micaela Mathia 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 190 KB 👁 2 views

## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H