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A novel missense MSH2 gene mutation in a patient of a Korean family with hereditary nonpolyposis colorectal cancer

✍ Scribed by Seo-Jin Park; Kyung-A. Lee; Tae Sung Park; Nam Kyu Kim; Jaewoo Song; Bo-Young Kim; Jong Rak Choi

Book ID: 113513314
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 245 KB
Volume: 182
Category: Article
ISSN: 0165-4608
DOI: 10.1016/j.cancergencyto.2008.01.011

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal disorder caused by mutations in DNA mismatch repair (MMR) genes. Tumors of the HNPCC‐spectrum are associated with microsatellite instability (MSI) and loss of MMR protein expression. Lymphomas are not considered to be HNP