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Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population

✍ Scribed by Maniamparmpil Shashidharan; Thomas Smyrk; Kevin M. Lin; Charles A. Ternent; Alan G. Thorson; Garnet J. Blatchford; Mark A. Christensen; Henry T. Lynch

Publisher: Springer
Year: 1999
Tongue: English
Weight: 840 KB
Volume: 42
Category: Article
ISSN: 0012-3706
DOI: 10.1007/bf02236925

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H