Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population
β Scribed by Kevin M. Lin; M. Shashidharan; Charles A. Ternent; Alan G. Thorson; Garnet J. Blatchford; Mark A. Christensen; Stephen J. Lanspa; Stephen J. Lemon; Patrice Watson; Henry T. Lynch
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 661 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0012-3706
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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H