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Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population

✍ Scribed by Kevin M. Lin; M. Shashidharan; Charles A. Ternent; Alan G. Thorson; Garnet J. Blatchford; Mark A. Christensen; Stephen J. Lanspa; Stephen J. Lemon; Patrice Watson; Henry T. Lynch


Publisher
Springer
Year
1998
Tongue
English
Weight
661 KB
Volume
41
Category
Article
ISSN
0012-3706

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H