New derivatives of quinuclidine as potential antihypertensive agents
β Scribed by Lance L. Collins; Charles A. Papacostas; Samuel Elkin
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 294 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Three cyclic methyldopa analogs ( I I I a , 6, and c) were synthesized by hydrolysis of the appropriate spirohydantoins (V), which were obtained through the Bucherer synthesis. Amino acids ( I I I a and b ) and hydantoins (Va and c) were inactive against experimental tumors. The 5 hydantoins tested
Sprague-Dawley rats 50 days old induced breast tumors within 21-120 days of feeding. When testing against these tumors, 9-methoxyellipticine was found to be inactive at 30 mg./kg. i.p. and 60 mg./ kg. per 0s. Furthermore, some weight loss and toxicity were evidenced in both regimens.
0 2-Alkoxyiminoalkylmercaptans were treated with appropriate reagents by established procedures to prepare the corresponding "Bunte salts," 2-(2-alkoxyiminoalkyIthio)-2-imidazolines, 2-(2-alkoxyimino)alkyl dithiocarbonates, and ethyl 2-alkoxyiminoalkyl trithiocarbonates. Selected compounds were scre