New compounds: Acrylonitrile derivatives as potential antineoplastic agents
β Scribed by Edward O. Magarian; W. Lewis Nobles
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 164 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
A recent pharmacological screening of certain palkoxyphenylacetamides revealed their analgesic activity. This communication outlines the synthesis of some related compounds involving certain analgesically active pharmacophores which are thought to increase potency and decrease toxicity. Keyphrases
Three cyclic methyldopa analogs ( I I I a , 6, and c) were synthesized by hydrolysis of the appropriate spirohydantoins (V), which were obtained through the Bucherer synthesis. Amino acids ( I I I a and b ) and hydantoins (Va and c) were inactive against experimental tumors. The 5 hydantoins tested