## Abstract A new method is presented for the tritiation of aryl compounds with tritium gas which is conducted on the underivatized substrate. Combined directed ortho metallation and facile reduction of the carbonpotassium bond affords incorporation of tritium at high specific activity under mild c
New approaches to the synthesis of tritium labelled glitazones
β Scribed by Nick Bushby; John R. Harding; Angela Jordan; Goran N. Nilsson; Roger Simonsson; Karin Wiklund
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 77 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
The synt esis of 3H-labelled azidothymidine (AZT) from accomplished by column chromatography. The purity of the labelled compound was determined by high performance 1 iquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.
Sir, Latli and coworkers recently described a synthesis of tritium-labelled bilirubin by the reduction of biliverdin with sodium borotritiide. 1 They failed to note that an essentially identical, but faster and higher-yield, procedure was published in this journal by Hutchinson et al. in 1981 2 and
Sir, it has been brought to our attention that in our manuscript published in JLCR 1 we neglected to cite an earlier procedure by Hutchinson et al. 2 We regret this oversight, although our paper described improvements over previous procedures. For example, our manuscript describes for the first time
r e o f P h y s i o l o g i c a l Sciences, S l o v a k Academy o f Sciences, 84216 B r a t i s l a v a , Czechos l o v a k i a . I n s t i t u t e f o r Research, P r o d u c t i o n and A p p l i c a t i o n o f R a d i o i s otopes, R a d i o v h 1, 10227 Prague 10, C z e c h o s l o v a k i a .
## Abstract The solidβphase method for hydrogenolysis, hydrogenation and isotope exchange reactions is described. Its potential for tritium labelling of organic compounds including lipids, nucleotides, amino acids, peptides and pharmaceuticals is demonstrated. The influence of the reaction conditio