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Addendum to: synthesis of tritium-labeled bilirubin

✍ Scribed by Bachir Latli

Publisher: John Wiley and Sons
Year: 2008
Tongue: French
Weight: 35 KB
Volume: 51
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1538

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✦ Synopsis

Sir, it has been brought to our attention that in our manuscript published in JLCR 1 we neglected to cite an earlier procedure by Hutchinson et al. 2 We regret this oversight, although our paper described improvements over previous procedures. For example, our manuscript describes for the first time the synthesis of tritium-labeled bilirubin with specific activities ranging from 6.6 to 8.8 Ci/ mmol as well as HPLC methods for the purification and analysis of this material. In regards to the issue of the heterogeneity of our product; we believe that this simple, one step procedure is a useful alternative to the biosynthetically prepared material. The material that we prepared was actually similar to the commercially available bilirubin.

Thank you very much for bringing these concerns to our attention.

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