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Solid-phase reactions as approach to the synthesis of organic compounds labelled with tritium

✍ Scribed by Nikolay F. Myasoedov

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 221 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1445

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✦ Synopsis

Abstract

The solid‐phase method for hydrogenolysis, hydrogenation and isotope exchange reactions is described. Its potential for tritium labelling of organic compounds including lipids, nucleotides, amino acids, peptides and pharmaceuticals is demonstrated. The influence of the reaction conditions on the yield and specific radioactivity of the labelled compounds is considered. It is shown that results can be interpreted by the dependence of tritium spillover reactions on the nature of the initial compound and other factors. Copyright © 2007 John Wiley & Sons, Ltd.

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