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Negative Regulation of Toll-Like Receptor Signaling by NF- B p50 Ubiquitination Blockade

โœ Scribed by Carmody, R. J.; Ruan, Q.; Palmer, S.; Hilliard, B.; Chen, Y. H.


Book ID
126837527
Publisher
American Association for the Advancement of Science
Year
2007
Tongue
English
Weight
516 KB
Volume
317
Category
Article
ISSN
0036-8075

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Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n