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Dissecting negative regulation of Toll-like receptor signaling

✍ Scribed by Takeshi Kondo; Taro Kawai; Shizuo Akira


Book ID
119263098
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
500 KB
Volume
33
Category
Article
ISSN
1471-4906

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Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n