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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

✍ Scribed by Mansell, Ashley; Smith, Rosealee; Doyle, Sarah L; Gray, Pearl; Fenner, Jennifer E; Crack, Peter J; Nicholson, Sandra E; Hilton, Douglas J; O'Neill, Luke A J; Hertzog, Paul J


Book ID
109923208
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
368 KB
Volume
7
Category
Article
ISSN
1529-2908

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Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n