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MYCN gain and MYCN amplification in a stage 4S neuroblastoma

✍ Scribed by Rosa Noguera; Adela Cañete; Antonio Pellı́n; Amparo Ruiz; Marı́a Tasso; Samuel Navarro; Victoria Castel; Antonio Llombart-Bosch

Book ID
114135481
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
141 KB
Volume
140
Category
Article
ISSN
0165-4608

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Concomitant p53 mutation and MYCN amplif
Concomitant p53 mutation and MYCN amplification in neuroblastoma
✍ Manhani, Reinaldo; Cristofani, Lilian Maria; Filho, Vicente; Bendit, Israel 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views

The MYCN oncogene is amplified in 20% of childhood neuroblastoma and is associated independently with poor prognosis. Alteration of the p53 tumor supressor gene, in contrast, occurs infrequently in these tumors. In this report, we described a 3-year-old girl with stage IV neuroblastoma. Molecular an