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MYCN-status in neuroblastoma: characteristics of tumours showing amplification, gain, and non-amplification

✍ Scribed by Ruediger Spitz; B. Hero; M. Skowron; K. Ernestus; F. Berthold


Book ID
116428239
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
195 KB
Volume
40
Category
Article
ISSN
0959-8049

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Amplification of the MYCN gene is significantly associated with an unfavorable prognosis and rapid progression in human neuroblastoma tumors. One potential mechanism by which MYCN may cause these effects is by deregulating cell proliferation. Tissue culture experiments support a model in which MYC g