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Clinical relevance of CD44 cell surface expression and MYCN gene amplification in neuroblastoma

✍ Scribed by V Combaret; N Gross; C Lasset; D Frappaz; C Beretta-Brognara; T Philip; D Beck; M.C Favrot

Book ID: 117663959
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 113 KB
Volume: 33
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(97)00236-0

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## Abstract The CD44 adhesion receptor is silenced in highly malignant neuroblastomas (NBs) with __MYCN__ amplification. Because its functional expression is associated with decreased tumorigenic properties, __CD44__ behaves as a tumor suppressor gene in NB and other cancers. Given that the precise