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MYCN Gene Amplification: Identification of Cell Populations Containing Double Minutes and Homogeneously Staining Regions in Neuroblastoma Tumors

✍ Scribed by Maisa Yoshimoto; Silvia Regina Caminada de Toledo; Eliana Maria Monteiro Caran; Maria Teresa de Seixas; Maria Lucia de Martino Lee; Simone de Campos Vieira Abib; Sonia Maria Rossi Vianna; Sergio Thomaz Schettini; Joyce Anderson Duffles Andrade

Book ID: 117022733
Publisher: American Society for Investigative Pathology
Year: 1999
Tongue: English
Weight: 203 KB
Volume: 155
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65457-0

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Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi