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Concomitant DDX1 and MYCN gain in neuroblastoma

✍ Scribed by Raffaella Defferrari; Gian Paolo Tonini; Massimo Conte; Filippo Papio; Angela Rita Sementa; Alexander Valent; Francesca Schena; Patrizia Perri; Katia Mazzocco

Book ID
116334469
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
439 KB
Volume
256
Category
Article
ISSN
0304-3835

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A DEAD box gene (DDXI) characterized by a motif with a putative RNA helicase was found at elevated levels, with multiple copies, in a neuroblastorna and in some retinoblastoma cell lines in which the MYCN gene was amplified. The present study was aimed at determining whether amplification o f the DD