𝔖 Bobbio Scriptorium
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Multiple solid phase synthesis of (RS)-1-aminophosphinic acids

✍ Scribed by E.Andrew Boyd; Weng C. Chan; Vincent M. Loh Jr.


Book ID
103407716
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
204 KB
Volume
37
Category
Article
ISSN
0040-4039

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The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr