Solid-Phase Synthesis of an α-Aminophosphine Library
✍ Scribed by Bar-Nir Ben-Aroya, Batia; Portnoy, Moshe
- Book ID
- 111957838
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 46 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1520-4766
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📜 SIMILAR VOLUMES
Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase
The solid support synthesis of a series of l-aminohydantoins based on a diverse set of hydrazino amino acids, aldehydes, and amines is described. The method involves the construction of resin attached hydrazino acid precursors, followed by subsequent derivatization, and then cyclizative cleavage off