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Combined solid phase and solution synthesis of a library of α,α-disubstituted-α-acylaminoketones

✍ Scribed by Javier Garcia; Ernesto Nicolàs; Fernando Albericio; Enrique L. Michelotti; Colin M. Tice

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
134 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase and solution steps.

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