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Solid phase synthesis of α-acylamino-α,α-disubstituted ketones

✍ Scribed by Colin M. Tice; Enrique L. Michelotti; Ernesto G. Mata; Ernesto Nicolàs; Javier Garcia; Fernando Albericio

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
150 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-a,a-disubstituted amino acid immobilized through its carboxylate as a Weinreb amide derivative.

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