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Synthesis of fluorinated α-amino ketones. Part II: α-acylaminoalkyl α′, α′-difluoroalkyl ketones

✍ Scribed by Michael Kolb; Bernhard Neises


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
241 KB
Volume
27
Category
Article
ISSN
0040-4039

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Solid phase synthesis of α-acylamino-α,α
✍ Colin M. Tice; Enrique L. Michelotti; Ernesto G. Mata; Ernesto Nicolàs; Javier G 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 150 KB

a-Acylamino-a,a-disubstituted ketones are of interest as ecdysone agonists. Solid phase synthesis of prototypical a-acylamino-a,a-disubstituted ketones on two different solid supports is described. In both cases the ketone was formed by reaction of a Grignard reagent with an N-acyl-a,a-disubstituted