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Synthesis of fluorinated α-amino ketones part I: α-benzamidoalkyl mono- di- and trifluoromethyl ketones

✍ Scribed by Michael Kolb; Jacqueline Barth; Bernhard Neises


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
232 KB
Volume
27
Category
Article
ISSN
0040-4039

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Synthesis of fluorinated α-amino ketones
✍ Kolb, Michael ;Neises, Bernhard ;Gerhart, Fritz 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 688 KB

## Abstract The synthesis of α‐amino mono‐, di‐, and trifluoromethyl and difluoromethylene ketones and their derivatives is described. A one‐pot sequence related to the Dakin‐West reaction starts from amino acids and gives the corresponding fluorinated ketone analogues in good yields. The compounds