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One-Pot Synthesis of α-Hydroxy Ketones from Captodative Formyl(amino)alkenes.

✍ Scribed by Alexander Yu. Rulev; Vladimir V. Novokshonov; Yuri A. Chuvashev; Sergei V. Fedorov; Lyudmila I. Larina


Publisher
John Wiley and Sons
Year
2003
Weight
97 KB
Volume
34
Category
Article
ISSN
0931-7597

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One-Pot Synthesis of Trisubstituted 1,2-
✍ Coralie Kison; Till Opatz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

## Abstract A short synthesis of __N__,1,2‐trisubstituted vicinal amino alcohols by 1,2‐addition of deprotonated __N__‐monosubstituted α‐amino nitriles to aldehydes and subsequent one‐pot reduction of the intermediates with borane–THF is described. This procedure leads to the predominant formation