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Multiple genotoxic activities of ptaquiloside in human lymphocytes: Aneugenesis, clastogenesis and induction of sister chromatid exchange

✍ Scribed by Rui M. Gil da Costa; Patrícia Coelho; Rosa Sousa; Margarida M.S.M. Bastos; Beatriz Porto; João P. Teixeira; Isabel Malheiro; Carlos Lopes

Book ID
117983423
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
421 KB
Volume
747
Category
Article
ISSN
1383-5718

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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m