Induction of sister-chromatid exchanges in human lymphocytes by microsomal activation of benzene metabolites
โ Scribed by Kanehisa Morimoto; Sheldon Wolff; Akira Koizumi
- Book ID
- 113254485
- Publisher
- Elsevier Science
- Year
- 1983
- Weight
- 309 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0165-7992
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Abstract The frequency of sister chromatid exchange (SCE) in WIโ38 cells was estimated by the 5โbromodeoxyuridine (BrdUrd)โdye technique after one hour's exposure to cyclophosphamide (CY), NโmethylโNโฒโnitroโNโnitrosoguanidine (MNNG), 4โnitroquinolineโ1โoxide (4NQO), and maleic hydrazide (MH) wit