𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures

✍ Scribed by Ünal Egeli

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
51 KB
Volume
18
Category
Article
ISSN
0270-3211

No coin nor oath required. For personal study only.

✦ Synopsis

This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.

📜 SIMILAR VOLUMES

Influence of GSTT1 genotype on sister ch
Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes
✍ Tiina Ollikainen; Ari Hirvonen; Hannu Norppa 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 1 views

The genetic polymorphisms of glutathione S-trans-(50 mM) and 1.4 (150 mM) times greater among ferases (GSTs), which are involved in the metabolic the GSTT1 null individuals (4.83 at 50 mM, 18.98 inactivation of various toxicants, have been sug-at 150 mM) compared with the GSTT1 positive indigested t

Protection and induction of chromosomal
Protection and induction of chromosomal damage by vitamin C in human lymphocyte cultures
✍ Lusânia M. Greggi Antunes; Catarina S. Takahashi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 37 KB 👁 2 views

Some chemotherapeutic approaches have proposed the use of antioxidants such as vitamin C (VC) to minimize the cytotoxicity and damage induced in normal tissue by antitumor agents that produce free radicals. Nevertheless, VC can also be cytotoxic, genotoxic, and harmful when combined with antitumor a

Elevated sister chromatid exchange frequ
Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields
✍ M.A. Wahab; J.V. Podd; B.I. Rapley; R.E. Rowland 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB

## Abstract The in vitro cytomolecular technique, sister chromatid exchange (SCE), was applied to test the clastogenic potentiality of extremely low frequency (ELF) electromagnetic fields (EMFs) on human peripheral blood lymphocytes (HPBLs). SCE frequencies were scored in dividing peripheral blood