This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
Ultrasonic induction of sister chromatid exchanges in human lymphocytes
β Scribed by Michael Haupt; Alice O. Martin; Joe Leigh Simpson; M. Anwaruddin Iqbal; Sherman Elias; Alan Dyer; Rudy E. Sabbagha
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 626 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0340-6717
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π SIMILAR VOLUMES
Experiments have been performed to determine whether human lymphocytes in primary cultures can show an "adaptive" response to the induction of cellular lesions (manifested as a production of sister chromatid exchanges, SCEs) as previously found in bacteria and established human and mammalian cell li
The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. UV C irradiation promotes SCE dose-dependent in the range of 0-40 mJ/cm2. No difference of this phenomenon may be observed, compairing young volunteers (20-40 year