Induction of sister-chromatid exchange in human lymphocytes by vitamin B6
β Scribed by J. Dozi-Vassiliades; D. Mourelatos; A. Myrtsiotis
- Book ID
- 119092604
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 187 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0165-1218
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π SIMILAR VOLUMES
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. UV C irradiation promotes SCE dose-dependent in the range of 0-40 mJ/cm2. No difference of this phenomenon may be observed, compairing young volunteers (20-40 year