Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry
โ Scribed by Robert M. Valerio; Andrew M. Bray; Heather Patsiouras
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 273 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstra