AIbslBlmL-2-Amidophenol attached to a solid support can be converted to the corresponding benzoxazole by treatment with tdphenylphosphine and diathyl azodicarboxylate in THF at room temperature in high yield and purity. Β© 1997 l~lsevk~ ~Β’~mcΒ’ Lt(L The synthesis and screening of small molecule combin
Solid phase synthesis of aryl ethers via the mitsunobu reaction
β Scribed by Thomas A. Rano; Kevin T. Chapman
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 173 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A wide range of commercial diazodicarboxylates and phosphines were screened in an attempt to find purification-free conditions for application in parallel synthesis. The combination of immobilized triphenylphosphine and TMAD proved to be suitable for the synthesis of aryl ethers via the Mitsunobu re
## Abstract For Abstract see ChemInform Abstract in Full Text.
Mitsunobu reaction of chiral tertiary alcohol (S)-2 with phenol 3 provides the desired ether (R)-1 in moderate yields at elevated temperatures (80-100Β°C). The S N 2 displacement pathway is evident by complete inversion of the (S)-alcohol to (R)-ether.