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Efficient, mild, parallel and purification-free synthesis of aryl ethers via the Mitsunobu reaction

✍ Scribed by Eric Valeur; Didier Roche

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 300 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.04.099

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✦ Synopsis

A wide range of commercial diazodicarboxylates and phosphines were screened in an attempt to find purification-free conditions for application in parallel synthesis. The combination of immobilized triphenylphosphine and TMAD proved to be suitable for the synthesis of aryl ethers via the Mitsunobu reaction. Nine ethers were synthesized in good yield and excellent purity, the purification being limited to a filtration step.

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