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MK-0431 : Agent for Type 2 Diabetes and Dipeptidyl-peptidase IV (CD26) Inhibitor

โœ Scribed by L. A. Sorbera; J. Castaner


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract Key step in the improved synthetic pathway to sitagliptin (VII), a new DPPโ€IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).