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Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa

✍ Scribed by Rong-Jun Guo; Hajime Arai; Yasuhiko Kitayama; Hisaki Igarashi; Hiromichi Hemmi; Tomio Arai; Hiroyuki Hanai; Haruhiko Sugimura


Book ID
114431072
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
778 KB
Volume
51
Category
Article
ISSN
1320-5463

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i