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Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

โœ Scribed by Fleisher, A Steven; Esteller, Manel; Tamura, Gen; Rashid, Asma; Stine, O Colin; Yin, Jing; Zou, Tong-Tong; Abraham, John M; Kong, Dehe; Nishizuka, Satoshi


Book ID
110064408
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
326 KB
Volume
20
Category
Article
ISSN
0950-9232

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i