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Microsatellite instability and hMLH1 promoter hypermethylation in Richter’s transformation of chronic lymphocytic leukemia

✍ Scribed by Fülöp, Z; Csernus, B; Tímár, B; Szepesi, Á; Matolcsy, A


Book ID
110055347
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
281 KB
Volume
17
Category
Article
ISSN
0887-6924

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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i