## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote
Hypermethylation of the p15INK4B gene promoter in B-chronic lymphocytic leukemia
β Scribed by Sotirios G. Papageorgiou; Stefanos Lambropoulos; Vassiliki Pappa; Christina Economopoulou; Frinta Kontsioti; Efstathios Papageorgiou; Panagiotis Tsirigotis; John Dervenoulas; Theofanis Economopoulos
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 82 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 Ψ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a
The novel human pre-B cell line OZ was established from a patient with an aggressive form of non-Hodgkin's lymphoma. Karyotypic analysis of both the primary tumour and OZ cells revealed several marker chromosomes, including the t(14;18)(q32;q21) translocation, which involves the Bcl-2 gene, and alte