The role of splenic irradiation in chronic lymphocytic leukemia
β Scribed by Roger W. Byhardt; Kirkland C. Brace; Peter H. Wiernik
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 407 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0008-543X
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The prognostic value of lymphocyte doubling time (LDT), expressed in months and obtained by means of a linear regression, has been studied in 99 previously untreated chronic lymphocytic leukemia (CLL) patients. LDT is defined as the period of time needed for lymphocytes to double in number the amoun
In 22 patients with CLL given 30 courses of spleen irradiation, 23 responses were observed (77%, 95% confidence limits, 58-90%). Response was defined as reduction in palpable spleen size accompanied by relief of symptoms (pain, abdominal discomfort, and sweating) or improvement in hypersequestration
Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 k 0.06 versus 1.10 k 0.02 pg/ml, P < 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the l