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Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability

✍ Scribed by Jens Plaschke; Uta Schwanebeck; Steffen Pistorius; Hans D Saeger; Hans K Schackert


Book ID
117467630
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
108 KB
Volume
191
Category
Article
ISSN
0304-3835

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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC