## Abstract It is generally accepted that both dysfunction of the Wnt signaling pathway, including mutations in the adenomatous polyposis coli (__APC__) and β‐catenin genes, and genetic instability play important roles in colorectal carcinogenesis. However, alteration of the components in the Wnt s
Differential transcriptional profile of the Wnt pathway in sporadic colorectal cancers with and without microsatellite instability
✍ Scribed by P. Ortega; A. Morán; C. De Juan; C. Frías; T. Fernández-Marcelo; A. Sánchez-Pernaute; S. Hernández; A.J. Torres; P. Iniesta; M. Benito
- Book ID
- 119598458
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 93 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-6349
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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC
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