CLINICO-PATHOLOGICAL FEATURES AND p53 EXPRESSION IN LEFT-SIDED SPORADIC COLORECTAL CANCERS WITH AND WITHOUT MICROSATELLITE INSTABILITY

✍ Scribed by ILYAS, M.; TOMLINSON, I. P. M.; NOVELLI, M. R.; HANBY, A.; BODMER, W. F.; TALBOT, I. C.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 751 KB
• Volume: 179
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/(sici)1096-9896(199608)179:4<370::aid-path627>3.0.co;2-n

✦ Synopsis

Defects in mismatch repair (MMR) can result in the development of a 'mutator phenotype', manifest as an increase in DNA replication errors (RERs). Patients with hereditary non-polyposis colorectal cancer (HNPCC) have germline mutations in MMR genes. These patients develop carcinomas of the colon and other specific sites a t a significantly earlier age than patients with sporadic carcinomas. RERs are found in the cancers from patients with HNPCC and have been demonstrated in 10-20 per cent of sporadic colorectal cancers (CRCs). Loss of MMR may simply accelerate tumour development, but it is also possible that these tumours follow a different carcinogenetic pathway from tumours with intact MMR. In particular, it has been suggested that p53 mutations occur less often in RER-positive (RER +) sporadic colorectal cancers. In this study, the clinico-pathological features and frequency of p53 overexpression in 17 left-sided RER+ CRCs were compared with 35 left-sided RER -CRCs. No differences were found in the age and tumour stage a t presentation, mucinous differentiation, or Jass prognostic grouping bctrvcen these two types of CRC. Thirteen out of 17 (76 per cent) RER+ and 19/35 (54 per cent) RERtumours showed overexpression of p53, a non-significant difference or2 test).

Although Some previous studies have suggested differences in the clinico-pathological features and p53 expression of RER+ and RERright-sided CRCs, our results show that these differences do not exist in left-sided cancers.