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Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings: Parallel Pathways of Tumorigenesis

✍ Scribed by Joanne Young; Lisa A. Simms; Kelli G. Biden; Coral Wynter; Vicki Whitehall; Rozemary Karamatic; Jill George; Jack Goldblatt; Ian Walpole; Sally-Anne Robin; Michael M. Borten; Russell Stitz; Jeffrey Searle; Diane McKeone; Leigh Fraser; David R. Purdie; Kay Podger; Rachael Price; Ron Buttenshaw; Michael D. Walsh; Melissa Barker; Barbara A. Leggett; Jeremy R. Jass

Book ID
117021458
Publisher
American Society for Investigative Pathology
Year
2001
Tongue
English
Weight
979 KB
Volume
159
Category
Article
ISSN
0002-9440

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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC