Sporadic Versus Hereditary forms of Colorectal Cancer with the DNA Microsatellite Instability Phenotype: to ‘lump’ or ‘Split’?

Differential involvement of the hypermet

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability

✍ Hiroyuki Yamamoto; Yongfen Min; Fumio Itoh; Arisa Imsumran; Shina Horiuchi; Mio 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 76 KB

## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC