Genetic polymorphisms of methyltetrahydrofolate reductase in patients with sporadic and hereditary nonpolyphosis colorectal cancer with microsatellite instability
β Scribed by Akoglu, Bora; Kindl, Petra; Weber, Nicole; Faust, Dominik; Caspary, Wolfgang; Trojan, Jorg
- Book ID
- 122711229
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 265 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
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Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome linked to DNA-mismatch-repair (MMR) gene defects, which also account for microsatellite instability (MSI) in tumour tissues. Diagnosis is based mainly on family history, according to widely accepted criteria (Amste
## Abstract Highβfrequency microsatellite instability (MSIβH) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSIβH colorectal tumors in HNPCC
Conflicting data exist on the prognosis of hereditary colorectal cancer. HNPCC patients, in particular, are often reported to have a better survival. We examined 2,340 colorectal-cancer patients treated in our Institution: 144 HNPCC patients (Amsterdam Criteria), 161 FAP patients and 2,035 patients