Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer?
โ Scribed by Britta Halvarsson; Annika Lindblom; Eva Rambech; Kristina Lagerstedt; Mef Nilbert
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 368 KB
- Volume
- 444
- Category
- Article
- ISSN
- 1432-2307
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## Abstract Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA an
## Abstract ## Background and Objectives The frequency of microsatellite instability (MSI) in young patients with colorectal cancer was evaluated, including reexamination of the medical and family history of each patient, and interviews with the patients to determine any possible new occurrence of
## Abstract Confounding effects of specific __KRAS__ gene alterations on colorectal cancer (CRC) prognosis stratified by microsatellite instability (MSI) and __BRAF__^__V600E__^ have not yet been investigated. The aim of our study was to evaluate the combined effects of MSI, __BRAF__^__V600E__^ and