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Methotrexate and 7-hydroxy-methotrexate pharmacokinetics following intravenous bolus administration and high-dose infusion of methotrexate

✍ Scribed by Bore, Patrick; Bruno, Rene; Lena, Nicole; Favre, Roger; Cano, Jean Paul

Book ID
120533109
Publisher
Elsevier Science
Year
1987
Weight
600 KB
Volume
23
Category
Article
ISSN
0277-5379

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✍ Heiko Iven; Helmut Brasch; JΓΆrg Engster πŸ“‚ Article πŸ“… 1985 πŸ› Springer 🌐 English βš– 551 KB

In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant