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Metalloproteinase activity in growth plate chondrocyte cultures is regulated by 1,25-(OH)2D3 and 24,25-(OH)2D3 and mediated through protein kinase C

โœ Scribed by S Maeda; D.D Dean; V.L Sylvia; B.D Boyan; Z Schwartz


Book ID
117640226
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
199 KB
Volume
20
Category
Article
ISSN
0945-053X

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Prior studies have shown that 24,25-(OH) 2 D 3 and 1,25-(OH) 2 D 3 regulate protein kinase C (PKC) in costochondral chondrocytes in a cell maturation-dependent manner, with 1,25-(OH) 2 D 3 affecting primarily growth zone (GC) cells and 24,25-(OH) 2 D 3 affecting primarily resting zone (RC) cells. In