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The effect of 24R,25-(OH)2D3 on protein kinase C activity in chondrocytes is mediated by phospholipase D whereas the effect of 1α,25-(OH)2D3 is mediated by phospholipase C

✍ Scribed by Z Schwartz; V.L Sylvia; M.H Luna; P DeVeau; R Whetstone; D.D Dean; B.D Boyan

Book ID
117213381
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
411 KB
Volume
66
Category
Article
ISSN
0039-128X

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Prior studies have shown that 24,25-(OH) 2 D 3 and 1,25-(OH) 2 D 3 regulate protein kinase C (PKC) in costochondral chondrocytes in a cell maturation-dependent manner, with 1,25-(OH) 2 D 3 affecting primarily growth zone (GC) cells and 24,25-(OH) 2 D 3 affecting primarily resting zone (RC) cells. In

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1a,25-(OH) 2 D 3 mediates its effects on growth zone chondrocytes via rapid membrane-associated events as well as through traditional nuclear receptor mechanisms. The membrane-associated signaling pathways include rapid production of diacylglycerol and activation of protein kinase C (PKC), as well a